The availability of large pre-trained models is changing the landscape of Machine Learning research and practice, moving from a training from scratch to a fine-tuning'' paradigm. While in some applications the goal is to nudge'' the pre-trained distribution towards preferred outputs, in others it is to steer it towards a different distribution over the sample space. Two main paradigms have emerged to tackle this challenge: Reward Maximization (RM) and, more recently, Distribution Matching (DM). RM applies standard Reinforcement Learning (RL) techniques, such as Policy Gradients, to gradually increase the reward signal. DM prescribes to first make explicit the target distribution that the model is fine-tuned to approximate.

Fine-tuning adapts pretrained models for specific tasks but poses the risk of catastrophic forgetting (CF), where critical knowledge from pretraining is overwritten. To address the issue of CF in a general-purpose framework, we propose Low-damage Knowledge Implanting (LoKI), a parameter-efficient fine-tuning (PEFT) technique that utilizes recent mechanistic understanding of how knowledge is stored in transformer architectures. We compare LoKI against state-of-the-art PEFT methods in two real-world fine-tuning scenarios. The results show that LoKI demonstrates significantly better preservation of general capabilities. At the same time, its task-specific performance is comparable to or even surpasses that of full parameter fine-tuning and these PEFT methods across various model architectures. Our work bridges the mechanistic insights of LLMs' knowledge storage with practical fine-tuning objectives, enabling an effective balance between task-specific adaptation and the retention of general-purpose capabilities.

Creating an agent that performs well across multiple tasks and continuously incorporates new knowledge has been a longstanding goal of research on artificial intelligence.

Catastrophic forgetting is a longstanding challenge in continual learning, where models lose knowledge from earlier tasks when learning new ones. While various mitigation strategies have been proposed for Multi-Layer Perceptrons (MLPs), recent architectural advances like Kolmogorov-Arnold Networks (KANs) have been suggested to offer intrinsic resistance to forgetting by leveraging localized spline-based activations. However, the practical behavior of KANs under continual learning remains unclear, and their limitations are not well understood. To address this, we present a comprehensive study of catastrophic forgetting in KANs and develop a theoretical framework that links forgetting to activation support overlap and intrinsic data dimension. We validate these analyses through systematic experiments on synthetic and vision tasks, measuring forgetting dynamics under varying model configurations and data complexity. Further, we introduce KAN-LoRA, a novel adapter design for parameter-efficient continual fine-tuning of language models, and evaluate its effectiveness in knowledge editing tasks. Our findings reveal that while KANs exhibit promising retention in low-dimensional algorithmic settings, they remain vulnerable to forgetting in high-dimensional domains such as image classification and language modeling. These results advance the understanding of KANs' strengths and limitations, offering practical insights for continual learning system design.

Despite large language models (LLMs) have achieved impressive achievements across numerous tasks, supervised fine-tuning (SFT) remains essential for adapting these models to specialized domains. However, SFT for domain specialization can be resource-intensive and sometimes leads to a deterioration in performance over general capabilities due to catastrophic forgetting (CF). To address these issues, we propose a self-adaptive gradient-aware data selection approach (GrADS) for supervised fine-tuning of LLMs, which identifies effective subsets of training data by analyzing gradients obtained from a preliminary training phase. Specifically, we design self-guided criteria that leverage the magnitude and statistical distribution of gradients to prioritize examples that contribute the most to the model's learning process. This approach enables the acquisition of representative samples that enhance LLMs understanding of domain-specific tasks. Through extensive experimentation with various LLMs across diverse domains such as medicine, law, and finance, GrADS has demonstrated significant efficiency and cost-effectiveness. Remarkably, utilizing merely 5% of the selected GrADS data, LLMs already surpass the performance of those fine-tuned on the entire dataset, and increasing to 50% of the data results in significant improvements! With catastrophic forgetting substantially mitigated simultaneously. We will release our code for GrADS later.

Large Language Models (LLMs) have significantly advanced Natural Language Processing (NLP), particularly in Natural Language Understanding (NLU) tasks. As we progress toward an agentic world where LLM-based agents autonomously handle specialized tasks, it becomes crucial for these models to adapt to new tasks without forgetting previously learned information - a challenge known as catastrophic forgetting. This study evaluates the continual fine-tuning of various open-source LLMs with different parameter sizes (specifically models under 10 billion parameters) on key NLU tasks from the GLUE benchmark, including SST-2, MRPC, CoLA, and MNLI. By employing prompt engineering and task-specific adjustments, we assess and compare the models' abilities to retain prior knowledge while learning new tasks. Our results indicate that models such as Phi-3.5-mini exhibit minimal forgetting while maintaining strong learning capabilities, making them well-suited for continual learning environments. Additionally, models like Orca-2-7b and Qwen2.5-7B demonstrate impressive learning abilities and overall performance after fine-tuning. This work contributes to understanding catastrophic forgetting in LLMs and highlights prompting engineering to optimize model performance for continual learning scenarios.

Federated- and Continual Learning have been established as approaches to enable privacy-aware learning on continuously changing data, as required for deploying AI systems in histopathology images. However, data shifts can occur in a dynamic world, spatially between institutions and temporally, due to changing data over time. This leads to two issues: Client Drift, where the central model degrades from aggregating data from clients trained on shifted data, and Catastrophic Forgetting, from temporal shifts such as changes in patient populations. Both tend to degrade the model's performance of previously seen data or spatially distributed training. Despite both problems arising from the same underlying problem of data shifts, existing research addresses them only individually. In this work, we introduce a method that can jointly alleviate Client Drift and Catastrophic Forgetting by using our proposed Dynamic Barlow Continuity that evaluates client updates on a public reference dataset and uses this to guide the training process to a spatially and temporally shift-invariant model. We evaluate our approach on the histopathology datasets BCSS and Semicol and prove our method to be highly effective by jointly improving the dice score as much as from 15.8% to 71.6% in Client Drift and from 42.5% to 62.8% in Catastrophic Forgetting. This enables Dynamic Learning by establishing spatio-temporal shift-invariance.

The availability of large pre-trained models is changing the landscape of Machine Learning research and practice, moving from a "training from scratch" to a "fine-tuning'' paradigm. While in some applications the goal is to "nudge'' the pre-trained distribution towards preferred outputs, in others it is to steer it towards a different distribution over the sample space. Two main paradigms have emerged to tackle this challenge: Reward Maximization (RM) and, more recently, Distribution Matching (DM). RM applies standard Reinforcement Learning (RL) techniques, such as Policy Gradients, to gradually increase the reward signal. DM prescribes to first make explicit the target distribution that the model is fine-tuned to approximate.

A crucial capability of Machine Learning models in real-world applications is the ability to continuously learn new tasks. This adaptability allows them to respond to potentially inevitable shifts in the data-generating distribution over time. However, in Continual Learning (CL) settings, models often struggle to balance learning new tasks (plasticity) with retaining previous knowledge (memory stability). Consequently, they are susceptible to Catastrophic Forgetting, which degrades performance and undermines the reliability of deployed systems. Variational Continual Learning methods tackle this challenge by employing a learning objective that recursively updates the posterior distribution and enforces it to stay close to the latest posterior estimate. Nonetheless, we argue that these methods may be ineffective due to compounding approximation errors over successive recursions. To mitigate this, we propose new learning objectives that integrate the regularization effects of multiple previous posterior estimations, preventing individual errors from dominating future posterior updates and compounding over time. We reveal insightful connections between these objectives and Temporal-Difference methods, a popular learning mechanism in Reinforcement Learning and Neuroscience. We evaluate the proposed objectives on challenging versions of popular CL benchmarks, demonstrating that they outperform standard Variational CL methods and non-variational baselines, effectively alleviating Catastrophic Forgetting.

Integrating deep learning into medical imaging is poised to greatly advance diagnostic methods but it faces challenges with generalizability. Foundation models, based on self-supervised learning, address these issues and improve data efficiency. Natural domain foundation models show promise for medical imaging, but systematic research evaluating domain adaptation, especially using self-supervised learning and parameter-efficient fine-tuning, remains underexplored. Additionally, little research addresses the issue of catastrophic forgetting during fine-tuning of foundation models. We adapted the DINOv2 vision transformer for retinal imaging classification tasks using self-supervised learning and generated two novel foundation models termed DINORET and BE DINORET. Publicly available color fundus photographs were employed for model development and subsequent fine-tuning for diabetic retinopathy staging and glaucoma detection. We introduced block expansion as a novel domain adaptation strategy and assessed the models for catastrophic forgetting. Models were benchmarked to RETFound, a state-of-the-art foundation model in ophthalmology. DINORET and BE DINORET demonstrated competitive performance on retinal imaging tasks, with the block expanded model achieving the highest scores on most datasets. Block expansion successfully mitigated catastrophic forgetting. Our few-shot learning studies indicated that DINORET and BE DINORET outperform RETFound in terms of data-efficiency. This study highlights the potential of adapting natural domain vision models to retinal imaging using self-supervised learning and block expansion. BE DINORET offers robust performance without sacrificing previously acquired capabilities. Our findings suggest that these methods could enable healthcare institutions to develop tailored vision models for their patient populations, enhancing global healthcare inclusivity.